ENDpoiNTs

Novel testing methods for endocrine disruption linked to developmental neurotoxicity
04/11/2024

Media

The third animation shows the final results of the ENDpoiNTs project

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03/11/2024

Our Research

Development of integrated platform of in vivo, in vitro and in silico methods for testing chemicals for ED properties impacting on neurodevelopment.

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10/04/2024

ENDpoiNTs final conference

ENDpoiNTs final conference

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The European project ENDpoiNTs was running between 2019-2024 and focused on developing new testing and screening methods to identify endocrine disrupting chemicals (EDCs) that induce human developmental  neurotoxicity (DNT). Its main outcomes are: 

  • Increased evidence base for endocrine disruptors’ effects on neurodevelopment in children
  • Improved PBTK models for predicting exposures of the developing brain
  • Identification of hormonal pathways relevant for neurodevelopment and generated 21 new QSARS, 6 in vitro assays and 1 in vivo (xenopus) towards those.     
  • Integrated OMICs data across test systems (in vitro and in vivo) to identify markers linking endocrine disruption to neurodevelopmental outcomes. 
  • 4 new adverse outcome pathways (AOPs) and 1 new AOP network based on ENDpoiNTs data to plausibly/casually link endocrine disruption and developmental neurotoxicity.
  • A database through which most generated data is publicly available

Some of the ENDpoiNTs results are taken further towards regulatory use in projects like PARC and PEPPER.